Deftly combining brain science with unforgettable case histories, Dr. Theodore Henderson explains exactly how the brain changes as a result of depression and how antidepressants work to reverse these changes. Gone are the chemical imbalance theories. Gone are the pull-yourself-up-by-the-bootstraps admonishments.

A real-world picture of depression is presented with moving stories that makes the science breathe. Dr. Henderson shows how ketamine infusion therapy is not a feared street drug, but a clinical tool and a window into curing depression. He provides real-world guidance to those who suffer with depression and for their loved ones.

Moreover, he addresses everyone’s worst fear – what if ketamine doesn’t work for me? He introduces other novel and powerful treatments for depression, as well as addressing childhood trauma, brain injury, and the importance of mindfulness.

In this deeply informed book, Dr. Henderson guides the reader to understanding the brain, depression, and antidepressants in a sometimes poignant, sometimes gritty, no-holds barred, real-world look at depression and recovery.